Best Cold Sore Products: Tested & Reviewed - NOV 2025

If you’re dealing with the pain and embarrassment of cold sores, it’s tempting to reach for a topical cream to numb the discomfort. But that’s a reactive fix — one that rarely promotes true healing or prevents future outbreaks. Why only manage symptoms when you can support your body’s healing process and boost your immune system?

Supplements with L-lysine and immune-supporting nutrients may help relieve cold sores and reduce their frequency. They can also strengthen your body’s natural defenses. We reviewed and ranked the top 10 cold sore supplements based on dosage, absorption, and ingredient quality to help you find lasting relief.